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Unlike the conventional small molecule inhibitors, the PROTAC technology possesses its unique catalytic mode of action

So, the problem doesnt appear to be directly driven by hyperglycemia but possibly by other factors related to oxidative stress and inflammation two major culprits in chronic diseases like diabetes

We further hypothesized that melatonin supplementation could improve the success rate of ART by increasing the quality of oocytes and embryos, increasing pregnancy rates, reducing oxidative stress, and promoting overall reproductive health

J Biol Chem 271 : 2965929665