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By examining the existing literature, this research seeks to provide a holistic understanding of the role oxidative stress plays in the development of T21 and to explore novel approaches that target multiple aspects of antioxidant intervention to improve cognitive function in individuals with Down syndrome

428 Furthermore, secondary senescence can occur due to inflammatory and fibrotic factors such as CCL2, IL-1b, IL-6, IL-8, and TGF-

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Based on the above results, abnormal meiotic development in germ cells may lead to adverse pregnancy outcomes, such as abnormal primordial follicle assembly, germ cell loss, and an increased abortion rate