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Furthermore, esculetin (5 mg/kg) can inhibit the production of NO, TNF-, IL-6, iNOS and nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing in DSS-induced colitis rats by inhibiting the activation of the NF-B and MAPK signaling pathways (86,87)

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Biochemical studies have not succeeded in identifying conclusively the basis of resistance in any type of cell selected with cDDP, but they have defined several mechanisms that can contribute to resistance

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Single-cell gel electrophoresis (Comet assay) For alkaline comet, lung tissue was homogenized in 1 ml of PBS (Ph 7.4), and clean glass slides were prepared by dipping in 1% normal melting point agarose