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this may explain why periodontitis is linked to several chronic diseases, including cardiovascular and neurodegenerative disease

10.1016/j.neuint.2008.01.009 18 BakavayevS.ChetritN.ZvagelskyT.MansourR.VyazmenskyM.BarakZ.et al

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Interestingly, there is a gender difference in response to GH treatment with men being more responsive in terms of IGF-I generation and fat loss during therapy, most probably due to men having lower estrogen levels that negatively impact the effect of GH on IGF-I generation in the liver (38)