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4) Figure 4 described a resumptive overview of Wnt/-catenin signalling pathway targeted interventions in cancer therapy as follows: CPG049090, PKF115-584 and PKF222-815 are natural compounds that have been identified to disrupt the interaction of -catenin/TCF complex, suppressing the proliferation of colon cancer cells in vitro assays

GPx takes part in the reduction of H2O2 and lipid peroxides to water and lipid alcohols and the oxidation of GSH to GSSG

CURs pro-oxidant effects at high doses have also raised concerns about its potential to cause DNA damage and cellular toxicity

Currently, generally recognized is the multiple hit theory, which uses insulin resistance (IR) and obesity the first hit to increase free fatty acids (FFAs) and make the liver more susceptible to hepatotoxic injury