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Understanding the complex-I-ty of metformin action: limiting mitochondrial respiration to improve cancer therapy

Abbreviations GCLC: Glutamate cysteine ligase catalytic subunit GCLM: Glutamate cysteine ligase modifier subunit GSH: Reduced glutathione GSSG: Oxidized glutathione ROS: Reactive oxygen species C1q: Complement component 1q C3: Complement component 3 GSDMD: Gasdermin D GSDME: Gasdermin E DAM: Disease associated microglia DAA: Disease associated astrocyte Iba1: Ionized calcium-binding adapter molecule 1 GFAP: Glial fibrillary acidic protein NeuN: Neuronal nuclei HO1: Hemeoxygenase 1 CCL: CC Chemokine ligand CXCL: C-X-C motif ligand AD: Alzheimers disease App: Amyloid precursor protein A: Amyloid beta App : NL-G-F App knockin mouse NL-G-F References Guo, C., Sun, L., Chen, X

DOI: 10.1007/s11095-009-0045-6 DailyMed

2014;147:R131R141

PLOS ONE 14, e0215815.CrossRefGoogle ScholarPubMed Mantripragada, S (2002) A lipid based depot (DepoFoam technology) for sustained release drug delivery