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However, phase 2 results frequently attenuate in larger trials

eLife 3 , e01958 (2014)

phosphorus: 50 g

Since, in the brain, TREM2 is exclusively expressed in microglia (the brains key immune effector cells), and its activation can regulate the immunometabolic polarization of these cells, it makes sense that TREM2 plays an important role in the immunomodulatory mechanisms driving AD (Li and Zhang, 2018)