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Deficiency is also prevalent in seniors because the capacity to absorb vitamin B12 can diminish with age

We next interrogated the gene expression levels of Insr and Igf1r on CD4 + T helper cell subsets (Th1, Th2, Th17, Treg), which we generated in vitro by activating splenic CD4 + T cells in the presence of cytokines and antibodies that promote subset differentiation, as previously described 29

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Overall, these results suggest a cytoprotective role for IGF-1 in CD4 + T cells, particularly Th17 cells

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