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These transgenic mice showed significantly reduced plasma testosterone levels (18% of normal)[124] and the IGF-I deficiency was correlated with an ultrastructural analysis of mutant Leydig cells revealing a significant developmental delay, with fewer and smaller Leydig cells than normal

Abdomen or thigh

Therapy should be initiated and monitored only by qualified healthcare professionals

The binding was exclusive to IGFs and did not apply to insulin or proinsulin despite their structural similarities

The presence of DSIP-LI in several HPLC fractions from conditioned culture media indicates secretion of DSIP-LI from cultured pheochromocytoma cells