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Yet, starting in our mid-20s, our bodies make less of it and as we grow older and collagen in our bodies degrades, we experience the telltale signs of aging, including wrinkles, sagging skin, brittle nails and hair, aching joints, digestive issues, and more

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Expanding adipose depots develop localized hypoxia that activates hypoxia-inducible factor 1- (HIF-1)-dependent signaling cascades, establishing self-perpetuating cycles of matrix accumulation

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