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In the IRI model, elevated expression of the E3 Ub-protein ligase HMG-CoA reductase degradation protein 1 (HRD1) increases ubiquitinated degradation of the -catenin degradation complex, stabilizes -catenin proteins, and thereby enhances Wnt / -catenin signaling[50]

4.1 Pro-tumor immune mechanisms of LECs Basic mechanism through which LECs can directly promote tumor cell migration and invasion is by providing a route for cancer cells to enter the LVs and disseminate to distant sites (78, 97) ( Figure 3A )

Collagen and Elastin Stimulation GHK-Cu activates genes responsible for extracellular matrix synthesis while simultaneously suppressing those involved in matrix degradation

Munteanu and Schwartz, 2024)

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