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Similarly, no significant differences were observed between rat chondrocytes treated with catalpol (at concentrations ranging from 0 to 1000 mol/L) and untreated chondrocytes after 48 h, suggesting that catalpol does not exhibit toxicity to chondrocytes (Pang, 2023)

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While semaglutide and tirzepatide primarily reduce food intake through appetite suppression, retatrutide simultaneously increases energy expenditure