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However, the relative contributions of both the activation and subsequent attenuation of lipid catabolism in fasting-induced longevity remain poorly understood

10.1007/s00299-005-0110-5 154 ThatcherL

And 2) damage to the oligodendrocyte exerted by inflammatory molecules, brain resident cells, such as oligodendrocytes, astrocytes, and microglia or peripheral immune cells neutrophils or T-cells

[5] Ferlay J, Shin H, Bray F, et al

The disruption of the BBB has been faced as an opportunity to improve the delivery of drugs to the brain and in particular to malignant tumors [45,46,47]