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Inter-species differences in drug metabolism, immune responses, and liver regeneration capacity can affect the translatability of findings, thereby restricting the extrapolation of preclinical data to clinical settings

Note: there are quite a few additional hormones that are involved in these processes, but for simplicity we are just focusing on the two primary female sex hormones

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Note: The symbol y indicates that the peptide bond between Glu and Cys is formed between the carboxyl y of Glu and the amino group of Cys8

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