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A coherent mechanistic rationale is not the same as demonstrated synergy, and animal-model effect sizes do not translate cleanly to human dosing

The invasive front of confined breast tumors exhibits pronounced nuclear deformation, nuclear rupture, and DNA damage [195]

However, TNF- overexpression has also been linked to injury complications, particularly those mediated by macrophage responses

The first few weeks at each new dose level are when side effects are most intense your body is adjusting to a higher concentration of the drug