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In this review, we selected articles that include the protective effects of CoQ10 against the toxicity of various chemical and natural compounds including pharmaceuticals, metals, pesticides, etc

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The primary endpoint in this study was time to recurrence of a mood episode (manic, mixed or depressed episode) requiring intervention, which was defined as any of the following: discontinuation due to a mood episode, clinical intervention for a mood episode (e.g., initiation of medication or hospitalization), or Mania Rating Scale score 18 or a MADRS score 18 (on 2 consecutive assessments no more than 10 days apart)

The lack of appetite effects means there is no rebound hunger concern when discontinuing, and the absence of hormonal suppression means no post-cycle therapy is required

There is a rare potential for urinary tract infection, or urinary catheterization or skin discoloration, however these are not encountered frequently