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[76] If SOD1 in the intermembrane space becomes misfolded, substantial SOD1 aggregation may occur within this compartment, associated with electron transport chain dysfunction and mitochondrial ROS production (Figure 11)

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Histopathology of kidney tissues With expert precision in context with the histological evidence, kidney tissues were first fixed in 10% neutral buffered formalin for 10 days and later transferred to 70% ethanol for further processing