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Eur J Pharm Sci (2020) 152:105450

The following FBXO3 crRNA guides were ordered from IDT and used: sgFBXO3-3: GGAGGATTCCAGCAGAGACA sgFBXO3-4: TATCAAGTCATGATCCGCTG sgFBXO3-5: TGTTCATACCGAATTCACAA sgFBXO3-6: GACGTCGATACAGCTGCCGG Endpoint HiBiT protein degradation HiBiT reporter cells, generated as described above, were seeded into 384-well plates at 20,000 cells per well and treated with the indicated compounds and equivalent concentrations of DMSO for the time indicated in the experiment, usually 3, 24 or 72 h

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