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In this study, on the basis of in vivo self-assembly nanotechnology, we designed a PSMA-targeted nano-PROTAC with a proximity degradation effect

In NAFLD models, Cur reverses the elevated Firmicutes / Bacteroidetes ratio and reduced Akkermansia abundance (Hong et al., 2022), while concurrently upregulating expression of tight junction proteins Occludin and ZO-1, suppressing TLR4/NF-B pathway activation, and reducing LPS exposure, thereby alleviating hepatic inflammation (Hong et al., 2022)

PMID: 9186590, DOI: 10.1111/j.1749-6632.1997.tb51994.x

doi: 10.1016/j.ejphar.2016.03.063

Tissue samples were cut into pieces ~2 mm 3 with a sterile scalpel and enzymatically digested in 5 mL tubes with 4.7 mL DMEM F12 media (Gibco, 11320033) and manufacturer-recommended amounts of H, R, and A enzymes in the Tumor Dissociation Kit, human (Miltenyi Biotec, 130-095-929)