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How Needle Degradation Affects Medication Delivery A dull needle requires additional force to penetrate skin, causing the injection to feel more painful and potentially traumatizing surrounding tissue

the seeds have two different forms of alkaloids: isoquinoline alkaloids such as nigellicimine and pyrazol alkaloids including nigellidine and nigellicine

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Additionally, the company did not have sufficient measures in place to prevent contamination from both internal and external sources

Guorong Fan, [email protected] These authors have contributed equally to this work This article was submitted to Predictive Toxicology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers