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Patients who should NOT use it include those with uncontrolled diabetes, active malignancy or personal history of hormone-sensitive cancer, or pituitary disease

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The likely rationale for this decision is that animal studies have found dietary glucose (the sugar in food and drinks) can suppress GH levels in rats [8], and GH levels in humans are known to peak in the late evening, just before bedtime

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MK-677 bypasses them entirely