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Role of the coagulation system in the pathogenesis of sickle cell disease

Stabilizes capillaries and endothelium, preventing tissue breakdown in inflamed or injured areas

As illustrated in Figure 1, these PC-PUFAs can then undergo peroxidation by lipoxygenases (LOX), producing lipid hydroperoxides (PC-PUFA-OOH) that drive ferroptotic cell death unless detoxified by GPX4 (Reed et al., 2022)

Joint damage: MSU crystals within tophi chronically activate macrophages, polarizing them toward an M1 phenotype