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doi: 10.1038/s41598-021-86489-4 80 FerreiraA

Funding Jakub Othal was supported by grant from the Czech Science Foundation no

Analysis of specific motor symptoms using Huntingtons disease-specific rating scales also found significant treatment-related improvements in the severity of tremors and rigidity

Bromodomains are involved in the recognition of acetylated lysines on histones and can recruit chromatin remodeling enzymes, resulting in transcriptional activation or repression including of autophagy-related genes (Sakamaki et al., 2017)

Serum biomarkers such as PRO-C3 (a marker of active fibrogenesis) are also gaining attention due to their specificity for collagen formation and their integration into composite indices such as the ADAPT score [81, 82]