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Some dermatologists recommend: Using copper peptides once daily Avoiding simultaneous use with strong acids or high-strength vitamin C Alternating nights with retinoids rather than layering them together If your skin becomes irritated or inflamed, that is a sign to reduce frequency or discontinue use

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Important Note on the Evidence Base Important note on the evidence base: The preclinical AOD-9604 literature in obese mouse and Zucker rat models is consistent and reproducible