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(PubMed) Thompson PA, Ashbeck EL, Roe DJ, et al

In addition, in the Y-MESO-14 (human malignant pleural mesothelioma cell line) xenograft tumor model, fibrocyte-like cells mediated the resistance to bevacizumab by producing FGF2 14

A subsequent pilot study (n=12) comparing oral liposomal glutathione (500 mg twice daily for 2 weeks) found increases in GSH levels in whole blood, erythrocytes, and plasma, along with reductions in 8-isoprostane (a marker of oxidative stress) (Buonocore et al., Oxid Med Cell Longev, 2016) [16]

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Indeed, the early symptoms of IR in different individuals are not obvious, and the related symptoms are very complex, combining with screening indicators may provide more precise diagnosis for IR in the general population