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NNMT plays a key role in metabolic dysfunction, and its inhibition has been shown to reverse obesity-related changes in adipose tissue. Kraus et al., Cell Metabolism How 5-Amino-1MQ Works The primary mechanism behind 5-Amino-1MQ lies in its ability to inhibit nicotinamide N-methyltransferase (NNMT) an enzyme that is often overexpressed in fat cells, cancer cells, and aging tissues

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doi: 10.1038/s41589-024-01680-8, 156 ZhangN.JiangN.YuL.GuanT.SangX.FengY.et al

doi: 10.3389/fpubh.2018.00162

Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women