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123 proposed that BI-4394 effectively blocked enzymatic activity of MMP13 to reduce levels of collagen degradation markers, specifically C2C fragments

PMID: 14 WangRMurrayCSFowlerSJSimpsonADurringtonHJ

doi: 10.1016/S0006-8993(98)00064-X

Its putative trafficking to mitochondria has emerged as an important player as shown in a cohort of patients with established MASH, which exhibited increased free cholesterol content and high expression of the steroidogenic acute regulatory protein (STARD1) compared to patients with simple steatosis [87]