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The leap from gene expression signatures in cell culture to clinical benefit in living humans is exactly the leap this article is designed not to make

C., Martin, J

[DOI] [PubMed] [Google Scholar] 54.Zhou L., Yang K., Xu M., Andl T., Millar S.E., Boyce S., Zhang Y

In 2003, for example, a multi-year study published in Neuroendocrinology Letters found that epithalamin could normalize the basic functions of the human organism, potentially extending lifespan by improving cardiovascular, endocrine, immune, and nervous function, as well as homeostasis and metabolism.2 Several publications including two systematic reviews in Advances in Gerontology have corroborated such findings.3 4 Researchers believe that epitalons therapeutic qualities may be due to the following mechanisms of action: Telomere elongation Telomeres are caps of DNA sequences at the ends of chromosomes

This information lays the groundwork for kinetic modeling and deeper structural interpretation