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Unexpectedly, gene array and functional analyses reveal that PPARdelta improves hyperglycemia by boosting glucose flow through the pentose phosphate pathway and enhancing fatty acid synthesis

Gene expression of the ghrelin receptor was identified in pituitary adenomas, neoplastic thyroid tissue, breast cancer, prostate cancer cell lines, and ovarian tumors (Gaytan et al., 2005

Similar mechanisms are proposed in HD, where mHTT induces mitochondrial fragmentation and oxidative damage, promoting NLRP3-driven inflammation [115]

[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management

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