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The compound showed an in vitro NNMT IC 50 of approximately 1.2 M and did not inhibit related methyltransferases at concentrations tested

Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency or establish a causal relationship to drug exposure: Blood and lymphatic system disorders:hemolytic anemia, leukocytosis Cardiac disorders:cardiospasm, congestive heart failure, conduction block, orthostatic hypotension and syncope, palpitations, bradycardia, atrial fibrillation, myocardial infarction, cardiac arrest, arrhythmia, ventricular ectopic activity, including ventricular tachycardia and QT prolongation

Insurance coverage and cost are also important considerations in medication selection

Combination with GLP-1 RAs: Research has focused on the potential for dual-pathway modulation (amylin + GLP-1) to enhance weight and metabolic outcomes compared with monotherapy

Anticoagulant treatment