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References 1 New England Journal of Medicine REDEFINE 1Garvey WT et al

The construction of the network graph was facilitated using the igraph and ggraph packages (B) Venn diagram of the common downregulated DEGs among GSE14668, GSE96851 and ferroptosis-related genes (C) GO enrichment analysis and KEGG pathway analysis of upregulated ferroptosis-related DEGs (FRGs) (D) GO enrichment analysis and KEGG pathway analysis of downregulated FRGs (E) A network graph of the 55 FRGs (F) In Cytoscape, the maximum connectivity clustering (MCC) algorithm was used to identify the top 10 highly connected ferroptosis-related genes (G) Expression levels of the top ten ferroptosis-related gene biomarkers between the patients with HBV-ALF and normal controls in GSE14668 (H) Expression levels of the top ten ferroptosis-related gene biomarkers for patients with HBV-ALF and normal controls in GSE96851