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Finally, this relatively 'coarse-grained' mode of regulation is insufficient to precisely govern the bidirectional functions of ATF members or their heterodimeric interactions, limiting its ability to achieve fine-tuned control over their specific physiological and pathological activities

5,8 Water-soluble antioxidants, such as vitamin C can be found in cellular fluids like cytosol and cytoplasmic matrix, whereas vitamin E, lipoic acid, and carotenoids are lipid-soluble antioxidants and are mostly found in a cellular membrane