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Nonetheless, overall SCFA depletion (as seen with low-fiber diets or dysbiosis) is generally associated with worse outcomes in aging and neurodegeneration due to loss of their beneficial gut and brain effects

References Stier H

Prolactin and sex hormones levels in males with Parkinsons disease

This is consistent with reports 30 that LNPs consisting of commercially available ionizable lipids, such as DLin-MC3-DMA, can activate the immune system, resulting in CARPA, an acute immunologic response that can lead to anaphylactic-like shock

doi: 10.3390/nu12113401 [DOI] [PMC free article] [PubMed] [Google Scholar] 137.Gearhardt AN, Schulte EM