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While most peptide research programs begin with a specific therapeutic target and build a synthetic molecule to match, this compound emerged from a fundamentally different direction: isolation and characterization of a naturally occurring protective sequence, followed by decades of systematic investigation into its biological activity profile

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TCA (nortriptyline), anticonvulsive (gabapentin or pregabalin), opioid, neurolytic blocks, local anesthetic, and intratechal methylprednisolone injection are recommended in severe PHN treatment [2]