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However, it is notoriously difficult to recapitulate these levels ex vivo, probably due to the prolonged differentiation process or absence of physiological stimuli

J Orthop Surg

The copper ion in GHK-Cu exists in a coordination complex with the peptide's histidine and lysine residues, and this bond is thermodynamically unstable at temperatures above 8C

Of note, the protein levels of NRF1, an upstream regulator of TFAM and one of the traditional targets of PGC-1, also showed a significant decrease

Beyond metabolic regulation, peptides also modulate the immune system, impacting the development of chronic inflammatory diseases