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All three routes improved MCL healing, supporting the clinical observation that BPC-157 retains activity orally and topically (a property unusual among peptides), although effect sizes varied by route

The mechanisms are poorly understood but may involve modulation of neurotransmitter systems (dopaminergic, serotonergic), reduction of neuroinflammation, and protection against excitotoxicity

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This shift has encouraged the application of multi-omics strategies to integrate information derived from multiple biological layers, including genomic variations, epigenomic modifications, transcriptomic profiles, proteomic regulation, metabolic signatures, immune responses, and microbiome profiles