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The following 8 days, the plasma concentrations of GLP-1 QMP were consistently higher than those of GLP-1 WT, resulting in a 3.1-fold greater AUC value (Fig

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5f), likely due to the V196L substitution in SC7, which introduces a bulkier side chain that may strengthen interactions with neighboring residues and render the overall conformation more compact (Fig

In these contexts, iron chelation may fail to address the upstream drivers of cell death and may even activate alternative death pathways