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Description

In this study, we aim to enhance 5-FU efficacy in CRC by targeting glutathione-dependent antioxidant defenses with small-molecule inhibitors of SLC7A11, GLS, and G6PDH

Blair Murphy-Rose

The X-ray-derived data of small molecular fragments in complex with TGR used in this study to design the compounds here described are available in the PDB under accession codes 6FTC, 6FMU, 6FMZ, 6FP4, 2X99, 2X8G, 2X8H, 6ZST, 6ZP3, 6ZLP, 6ZLB, 7B02, 7NPX, 2V6O, 6RTJ, 6RTO, 6RTM, and 3H4K

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