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Such modulation is essential to mitigate the harmful consequences of reperfusion injury since it can be used to sustain cellular homeostasis and avoid a high inflammatory state (Yousefi Zardak et al., 2024)

As -KG enters the TCA cycle, it gets oxidized to generate succinate and fumarate, which are cancer metabolites that produce ATP, NADH, and FADH2 [34] (Fig

5.4 Cystine metabolism Cystine is a sulfur-containing amino acid formed by the oxidation of two cysteine molecules linked together by a disulfide bond

However, despite the growing consensus on their clinical relevance, the precise definition and identification of CSCs remain subjects of ongoing debate