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Access this article Similar content being viewed by others Abbreviations ADH: Alcohol dehydrogenase AIF: Apoptosis inducing factor AKI: Acute kidney injury ALF: Acute liver failure APAP: Acetaminophen ASK1: Apoptosis signal-regulating kinase 1 Cyp2E1: Cytochrome P450 2E1 DMSO: Dimethyl sulfoxide FDA: Food and Drug Administration (US) GSH: Reduced glutathione JNK: C-Jun N-terminal kinase MAPK: Mitogen activating protein kinase 4MP: 4-Methylpyrazole MKK4: Mitogen-activated protein kinase kinase 4 MPTP: Mitochondrial membrane permeability transition pore NAPQI: N -Acetyl- p -benzoquinone imine Nrf2: Nuclear factor erythroid 2-related factor 2 USNMS: United States National Multicenter Study References Akakpo JY, Ramachandran A, Kandel SE, Ni HM, Kumer SC, Rumack BH, Jaeschke H (2018) 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes

The inhibition of ChaC1 by covalent modification of the cysteine residues of the ChaC1 protein, therefore, presented itself as a likely possibility

Poor neurologic outcomes following an aneurysmal subarachnoid hemorrhage (aSAH) have been linked to inappropriate calcium-dependent contraction of arteries (known as cerebral arterial vasospasm), leading to delayed cerebral ischemia (63)

Tochikura TS, Nakashima H, Hirose K, et al