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To move beyond descriptive pathway enrichment and identify mechanistically relevant signaling programs, a focused gene set enrichment analysis (GSEA) was performed, emphasizing pathways associated with oxidative stress and innate immune activation

Glutathione production by our bodies naturally decreases with age, but can also be impacted by diet, physical activity, alcohol intake, infections, stress, certain medications, and chronic illness

Oral supplements rely on digestion and absorption, which may be limited for some patients

3.1 Mitochondria-associated metabolic reprogramming of macrophages Mitochondria serve as the central hub for macrophage metabolic plasticity, which plays an important role in energy production, immune regulation, signal transduction, and cell fate determination, intervening the inflammation regulation and macrophage repair (84)

Liver Int 42:10371048 Hayashi PH, Isabel Lucena M, Fontana RJ (2022) RECAM: a new and improved, computerized causality assessment tool for DILI diagnosis