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Certain groups are more at risk of a Vitamin D deficiency, but it seems that our current lifestyles have left us all more susceptible and in need of an added boost

The point of loading is not to feel a repeated boost, it is to bring low levels back up to a normal range before switching to a slower schedule

There is no controlled human trial data on these combinations

This figure is remarkable in the context of GLP-1 therapeutics: oral semaglutide (Rybelsus), despite incorporating the SNAC absorption enhancer, achieves oral bioavailability of only 0.4-1.0%, meaning that more than 99% of the ingested semaglutide peptide is lost to gastrointestinal degradation and poor absorption

Read more about what this means here.