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A research paper on the health and economic burden of smoking in 12 Latin American countries exposes how health-care costs attributable to smoking represent 6.9 per cent of the overall health budgets of these countries tax revenues from cigarette sales cover only 36 per cent of these expenditures

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Using an extract of cigarette tobacco or its isolated ingredients, such as nicotine, many in vitro studies have found that smoking is associated with reduced NO availability