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Sewell addresses this thoughtfully

209 Excessive hydrophobicity may lead to strong hemolytic toxicity, which may be caused by the self-binding of the peptides that may impede the peptides pass through prokaryotic cell membranes without hindering their passage through eukaryotic cell membranes

However, avoid combining with sedatives or anxiolytics without physician guidance

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Fialkow J (2016) Omega-3 fatty acid formulations in cardiovascular disease: dietary supplements are not substitutes for prescription products