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389 Additionally, IL-22 facilitates the development of thymic-derived peripheral T cells

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Studies using mouse models have confirmed that elevated HO-1 not only exacerbates the inflammatory response in macrophage-derived foam cells but also induces ferroptosis, resulting in a significantly increased plaque burden ( - / - Fbn1C1039G+/ - mice as a model showed a significant increase in HO-1 expression within carotid plaques (83)

A peroxidic role to oxidize a range of H donors (AH 2 ) DNA cleavage by X-ray and mitomycin C induced malignant transformation which was found to be suppressed by the catalase enzyme