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A possible explanation for these effects of folate on brain development and the risk of certain neurodevelopmental diseases may lie in epigenetic modifications, especially in DNA methylation pathways

This mixture was left on ice for 5 min before addition of neutralization buffer (final concentration, 0.17 mM ammonium carbonate (5330050050) in LCMS-grade H 2 O) and gently mixed before being incubated on dry ice for 15 min

Data availability All RNA-seq data have been deposited in the GEO and are accessible through GEO Series accession numbers GSE272456 (HCT116) and 810 GSE272391 (AKP organoids) or at RNA-seq data of the clinical cohort have previously been deposited at GSE103479 (ref

However, complex multidrug regimens increase patient burden and reduce compliance

KEAP1/NRF2 (NFE2L2) mutations in NSCLC Fuel for a superresistant phenotype