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In contrast, the majority of genes were significantly down-regulated, especially genes in translation (including ribosome and aminoacyl-tRNA biosynthesis pathways) process (Figure 3B and Figure S2)

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Future studies leveraging the genetic tractability of Drosophila could further dissect the molecular pathways influenced by such natural compounds, accelerating the discovery of novel AD therapeutics

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Another study was carried out to evaluate the effect of oral febuxostat on the endothelial dysfunction in patients with ESRD, which lead to the improvement in hyperuricemia and endothelial dysfunction by febuxostat with no safety concerns (36)