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By 2013, a study had identified the PGC-1/FNDC5/BDNF axis as a crucial bridge linking skeletal muscle metabolism to central neuroplasticity [29], further underscoring exercise and its mimetics as systemic regulators of brain health and opening new therapeutic avenues for neurodegenerative diseases

No funding or sponsorship was received for this study

Boeniger MF, Lowry LK, Rosenberg J: Interpretation of urine results used to assess chemical exposure with emphasis on creatinine adjustments: a review