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10.3389/fimmu.2019.02048 21 ChenY

Denis M

Figure 1 Glycolytically derived lactate conversion is principally catalyzed by lactate dehydrogenase (LDH)a tetrameric enzyme composed of LDHA or LDHB subunits

They found that PARx inhibited tumor growth, without the mice displaying signs or symptoms of off-target toxic effects such as weight loss or liver damage