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Prior studies have demonstrated that T cells exposed to PSA can synergize with tissue-resident FoxP3+ regulatory T cells (Tregs) to promote the secretion of the inhibitory cytokine IL-10 by Tregs, thereby effectively suppressing inflammatory cascade reactions and safeguarding lung health (123)

The freshly isolated human leukocytes were used immediately after isolation

The first evidence for these roles derives from observations made in patients with dysfunctional TNAP, which results in a rare disease called hypophosphatasia

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Singh J, Dubey RK, Atal CK (1986) Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content